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Complex Wounds Associated with Systemic Diseases and General Conditions

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At Wound and Burn Centers of America, we understand the challenges posed by complex wounds associated with systemic diseases and general conditions. Led by renowned physician Dr. Hajhosseini, our dedicated team specializes in addressing wounds caused by conditions like lymphedema, hidradenitis suppurativa, refractory osteomyelitis, and more. With our expertise and innovative treatments, we aim to provide comprehensive care and promote long-lasting healing for each patient we serve.

About Complex Wounds Associated with Systemic Diseases and General Conditions

Complex wounds, also known as chronic wounds, are wounds that fail to progress through the normal stages of healing. These wounds do not undergo an orderly and timely series of events to achieve complete closure and functional restoration. Systemic diseases and certain general conditions play a crucial role in the development of these wounds. Some conditions lead to skin ulceration, while others hinder the body’s healing potential. Identifying and addressing these underlying causes is vital for achieving long-lasting healing outcomes.

Systemic Diseases & General Conditions
That May Contribute To Complex Wounds:


Lymphedema is characterized by swelling in an arm or leg due to a blockage in the lymphatic system. This blockage prevents proper drainage of lymph fluid, leading to tissue swelling and impaired wound healing.

Hidradenitis Suppurativa

Hidradenitis suppurativa is a chronic inflammatory skin condition that causes painful lumps to form under the skin. These lumps typically develop in areas where the skin rubs together, such as the armpits, groin, buttocks, and breasts. The lumps can heal slowly, recur frequently, and sometimes result in tunnels under the skin and scarring, making wound healing challenging.

Refractory Osteomyelitis

Refractory osteomyelitis refers to a bone infection that does not respond well to standard treatments. It is often caused by bacteria that infiltrate the bone tissue, leading to chronic inflammation and impaired healing.

Pyoderma Gangrenosum is a rare immune system disorder characterized by the development of large, painful ulcers on the skin, most commonly on the legs. These ulcers can be difficult to heal due to underlying immune dysfunction and ongoing tissue damage.

Neuropathy refers to damage or dysfunction of motor or sensory nerves. Nerve damage can impair the body’s ability to sense and respond to injury, leading to delayed wound healing and an increased risk of developing chronic wounds.

Cancerous cells in the body can weaken the immune system and disrupt normal tissue healing processes. Cancer treatments such as chemotherapy and radiation therapy may also adversely affect wound healing.

Exposure to radiation, typically used in cancer treatment, can decrease the amount of oxygen in the radiated area. Reduced oxygen levels hinder wound healing by impairing cellular function and blood vessel formation.

Conditions such as autoimmune diseases, rheumatologic disorders (e.g., rheumatoid arthritis), and neuromuscular disorders can impact the immune system, joint health, muscle function, and overall tissue healing ability.

Certain genetic disorders can affect skin integrity and the body’s ability to heal wounds. These conditions often involve abnormalities in collagen production or connective tissue function, leading to impaired wound healing.

Inadequate nutrition and vitamin deficiencies can compromise the body’s ability to heal wounds. Essential nutrients, such as proteins, vitamins (e.g., vitamin C, vitamin A), and minerals (e.g., zinc), play critical roles in wound healing.

Certain medications can interfere with the wound healing process. For example, long-term use of steroids, immunosuppressants, cytotoxic chemotherapy agents, anticoagulants, and certain nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with poor healing outcomes. These medications may impact inflammation, immune response, blood clotting, or cell proliferation, affecting wound healing potential.

Why Choose Wound and Burn Centers
of America for Complex Wound Treatment?

Wound and Burn Centers of America is the premier choice for comprehensive complex wound treatment. With a team led by Dr. Babak Hajhosseini, a world-renowned wound healing specialist, we offer cutting-edge therapies and personalized care for patients with challenging wounds associated with systemic diseases and general conditions. Our multidisciplinary approach, innovative techniques, and commitment to excellence ensure the best possible outcomes. Schedule an appointment, and experience the difference we can make in your healing journey.

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Contact Us (424) 527-0011